Newcastle-led research finds surgery more effective than nasal sprays for symptoms of crooked septum

Adults with at least moderate symptoms can reliably be offered surgery, say researchers

Surgery to straighten a crooked septum (the thin wall of bone and cartilage dividing the space between the two nostrils) is more effective than nasal sprays, and should be offered to adults with at least moderate symptoms such as breathing disruption, suggests a UK trial published by the British Medical Journal.

A common operation

A crooked (deviated) septum often means that one nasal passage is narrower than the other, making it feel blocked, which can affect breathing, sleep or exercising.

Surgery to correct this (septoplasty) is a common operation. In 2019-20, 16,700 septoplasties were carried out in England, but there’s a lack of high quality evidence evaluating septoplasty and therefore no clear guidelines for its use.

To address this, a team of UK researchers designed the Nasal Airways Obstruction Study (NAIROS) to provide definitive evidence and recommendations for use of septoplasty.

The UK-wide trial was led by Mr Sean Carrie, consultant otolaryngologist (ENT) at Newcastle Hospitals, with Mr James O’Hara, honorary consultant otolaryngologist at Newcastle Hospitals and clinical senior lecturer at Newcastle University. It was supported by research nurse, Peter Wilson, who saw patients who were enrolled onto the trial.

The aim was to inform guidance on which patients may benefit from this treatment, and to standardise treatment across the UK.

Newcastle University and Newcastle Hospitals are both part of Newcastle Health Innovation Partners (NHIP). NHIP is one of eight prestigious Academic Health Science Centres (AHSCs) across the UK, bringing together partners to deliver excellence in research, health education and patient care.


The study involved 378 adults (average age 40; 67% men) with at least moderate symptoms of nasal obstruction linked to septal deviation, confirmed by a score of more than 30 on the Nasal Obstruction and Symptom Evaluation (NOSE) scale.

Participants were randomly assigned to receive either septoplasty (188) or medical management in the form of nasal steroid and saline spray (190).

At six months, patients completed the Sino-Nasal Outcome Test-22 (SNOT-22), which assesses 22 symptoms, each scored from zero to 5, with higher scores indicating worse symptoms. A 9 point difference on this scale was defined as the minimal clinically important difference.

Other outcomes included quality of life and nasal airflow measures. Potentially influential factors such as age, sex, and severity of symptoms at the start of the study, were also taken into account.

The average SNOT-22 scores at six months were 19.9 in the septoplasty group and 39.5 in the medical management group – 20 points lower (better) for those who received septoplasty.

Improvement in SNOT-22 scores in the septoplasty group remained at 12 months but to a lesser degree (21.2 compared with 30.4 in the medical management group).

Patients with more severe symptoms at the start of the study reported greater improvement after septoplasty compared with medical management. Quality of life outcomes and nasal airflow measures also improved more in participants in the septoplasty group.

Readmission to hospital with bleeding after septoplasty occurred in seven participants (4% of 174 who had septoplasty), and a further 20 participants (12%) required antibiotics for infections.

The researchers acknowledge that nasal obstruction can have many underlying possible causes, which they did not seek to diagnose or treat before randomisation, and say the experience of surgeons performing septoplasties – and the covid-19 pandemic – may also have affected their results.

Nevertheless, they conclude: “Septoplasty is a superior treatment for nasal obstruction associated with septal deviation compared with a defined regimen of nasal steroid and saline sprays.”

Initial NOSE scores can estimate the likely improvement in symptoms and guide decision making for patients and clinicians, they add. And they recommend that “adults presenting with nasal obstruction associated with a deviated nasal septum should be offered septoplasty.”

Landmark study

This new trial paves the way for evidence based guidelines, say experts in a linked editorial.

“At a time when the NHS and many other health systems are focused on tackling the backlog of patients awaiting operations, funding for surgical procedures is being closely examined to find cost savings, and clinicians have a responsibility to ensure the effectiveness of their treatments,” they write.

“These authors have produced a landmark study showing the efficacy of septoplasty over medical management in patients with nasal obstruction due to a deviated nasal septum. “It is vital that these findings now translate into guidance to ensure all patients with suitable pathology are offered this effective intervention,” they conclude.


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